Aug 15, 2016 systemic lupus erythematosus, the most common form of lupus, is a chronic autoimmune disease that can cause severe fatigue and joint pain. Systemic lupus erythematosus pathophysiology wikidoc. Renal assault during sle is initiated by genes that breach immune. The reported prevalence of systemic lupus erythematosus sle in the united states is 20 to 150 cases per 100,000. Systemic lupus systemic lupus erythematosus a multisystem autoimmune disease etiology unknown most common in women, young to most common in women, young to middleaged highly variable clinical presentation highly variable clinical presentation in individual patients harvardmit division of health sciences and technology. Systemic lupus erythematosus sle is an autoimmune disease in which the bodys immune system attacks its own healthy tissue. Systemic lupus erythematosus sle, lupus is characterized by a. The pathophysiology of systemic lupus erythematosus involves the immune system. Multiple genes contribute to disease susceptibility. Systemic lupus erythematosus clinical presentation youtube. Although both men and women of all age groups can be affected, women outnumber men almost 10 fold and. Immunologic abnormalities, especially the production of a number of antinuclear antibodies ana, are a prominent feature of the disease.
Systemic lupus erythematosus sle, or lupus is a systemic autoimmune disease with multiorgan inflammation. Systemic lupus erythematosus is the most common form of the disease. Systemic lupus erythematosus is an autoimmune disease that affects many systems, including the skin, musculoskel etal, renal, neuropsychiatric, hematologic, cardiovascular, pulmonary, and. Katarzyna gilekseibert, md abstract systemic lupus erythematosus sle is a chronic, compli cated and challenging disease to diagnose and treat. Systemic lupus erythematosus, the most common form of lupus, is a chronic autoimmune disease that can cause severe fatigue and joint pain. Clinical presentation, pathophysiology, and therapeutic strategies over the course of disease. Review this overview and discuss any symptoms you have with your doctor. Potential of chloroquine and hydroxychloroquine to treat. Systemic lupus erythematosus sle, is the most common type of lupus.
Systemic lupus erythematosus sle is a disease characterized by the production of autoreactive antibodies and cytokines, which are thought to have a major. Although the term lupus erythematosus was introduced by 19thcentury physicians to describe skin lesions, it took almost 100 years to realize that the disease is systemic and spares no organ. The pathogenesis of systemic lupus erythematosus an update. Pathophysiology of systemic lupus erythematosus flashcards. An extremely complicated and multifactorial interaction among various genetic and environmental factors is probably. Pathogenesis of human systemic lupus erythematosus.
Mar 18, 2020 systemic lupus erythematosus sle is an autoimmune disorder characterized by antibodies to nuclear and cytoplasmic antigens, multisystem inflammation, protean clinical manifestations, and a relapsing and remitting course. Although there is a possibility of having a genetic predisposition to the disease only 3 of 100 children of those diagnosed with systemic lupus erythematosus will go on to develop it. Potential of chloroquine and hydroxychloroquine to treat covid19 causes fears of shortages among people with systemic lupus erythematosus skip to main content thank you for visiting. It should be considered as a potential diagnosis in all patients who present with multiorgan system disease. Systemic lupus erythematosus an overview sciencedirect topics. More than 90% of cases of sle occur in women, frequently starting at childbearing age. Introduction systemic lupus erythematosus sle is a chronic autoimmune disease of unknown cause that can affect virtually any organ of the body. With regards to ethnic origin systemic lupus erythematosus is more prevalent in those with afrocaribean, asian or chinese ancestry. Systemic lupus erythematosus sle is the paradigm of systemic autoimmune diseases characterised by a wide spectrum of clinical manifestations with an unpredictable relapsingremitting course. Apr 20, 2020 systemic lupus erythematosus sle is an autoimmune disorder characterized by antibodies to nuclear and cytoplasmic antigens, multisystem inflammation, protean clinical manifestations, and a. Jan 09, 2018 learn the clinical presentation of lupus, including the genetic and environmental triggers, symptoms, cell damage and the bodys immune response. Sle is an autoimmune disease in which environmental triggers in genetically susceptible individuals results in the activation of the innate and adaptive immune response, leading to a loss of tolerance to ubiquitous selfantigens. The common manifestations are in the form of arthritis, skin rash, renal and hematological involvement along with fever and constitutional symptoms. Impaired erythropoietin response and presence of antibodies against erythropoietin may contribute to the pathogenesis of this type of anaemia.
Other factors such as genetic factors, hormonal abnormalities, and environmental factors also play a role. The pathophysiology of photosensitivity in lupus erythematosus. Apr 02, 2019 the pathophysiology of sle is thought to involve an interplay between genetics monozygotic twins and epigenetics, immunology factors, hormonal factors such as oestrogen and environmental factors. Systemic lupus erythematosus lupus is a chronic longlasting autoimmune disease that can affect many parts of the body. Systemic lupus erythematosus, its treatment, and future. Pdf pathogenesis of systemic lupus erythematosus researchgate. Systemic lupus erythematosus sle is an autoimmune disease with a prevalence of 36. Pediatric systemic lupus erythematosus american academy. Moulton,1, abel suarezfueyo,1 esra meidan,1,2 hao li, masayuki mizui,3 and george c. Pathophysiology of lupus pathophysiology of sle dr garys. Pathophysiology is defined as the study the biological and physical. Delayed diagnosis of sle and decreased quality of life warrant an improvement in classification as well as in. It can affect the joints, skin, brain, lungs, kidneys, and blood vessels. It usually follows a chronic course and hence can also be termed as a chronic disease.
Acces pdf professional guide to pathophysiology 3rd edition professional guide to pathophysiology 3rd edition. Pathogenesis of systemic lupus erythematosus c c mok, c s lau j clin pathol2003. Pathophysiology of lupus is currently being studied in all areas of the disease and many believe it could be a way to abolish the disease. Aberrant innate immune responses play a significant role in the pathogenesis of sle. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Anaemia is found in about 50% of patients, with anaemia of chronic disease being the most common form. In women, prevalence rates vary from 164 white to 406 african american per 100,000. There are various types of rashes in systemic lupus erythematosus sle, the. It is more common in african americans and people of american indian and asian descent than in white people. While systemic lupus can affect any area of the body.
The most important environmental factors involved in the pathogenesis of sle include ultraviolet uv light and some infections. Pathophysiology of systemic lupus erythematosus free download as powerpoint presentation. Nursing care plan for systemic lupus erythematosus sle. Pathogenesis 20 and clinical features 1 introduction systemic lupus erythematosus sle is the prototypic multisystem autoimmune disorder with a broad spectrum of clinical presentations encompassing almost all organs and tissues. Photosensitivity in lupus erythematosus dna damage the possibility that uv light is involved in the pathogenesis of systemic lupus erythematosus and lupus skin disease is supported by mechanistic studies. Sles an autoimmune disease that can affect any tissue or organ. Environmental factors that seem to trigger lupus include sunlight, stress, viruses, trauma and some medications. Lupus, technically known as systemic lupus erythematosus sle, is an autoimmune disease in which the bodys immune system mistakenly attacks healthy tissue in many parts of the body. Systemic lupus erythematosus sle signs and symptoms.
Patients with autoimmune haemolytic anaemia usually belong to a distinct. The diagnosis and treatment of systemic lupus erythematosus. Haematological abnormalities are common in systemic lupus erythematosus. Pathogenesis of systemic lupus erythematosus journal of clinical. Patients with sle are affected with the following condi. It may involve only a single organ, but in its due course, it usually involves multiple organs of the body. Its diversity of clinical features is matched by the complexity of the factors genetic, hormonal, and environmental that cause it, and the array of autoantibodies with which it is associated. Read an overview of the pathophysiology of systemic lupus. Systemic lupus erythematosus is a systemic autoimmune disease with a worldwide distribution.
Pathogenesis of human systemic lupus erythematosus cell press. Start studying pathophysiology of systemic lupus erythematosus. A good number of clinical practice guidelines are currently available on sle. Certain risk factors have been identified and shown to contribute to disease suscepti bility or activate the. It may affect virtually any organ or structure of the body, especially the skin, kidneys, joints, heart, gastrointestinal tract, brain, and serous membranes membranous linings of organs, joints, and cavities of the body. Autoantibodies to dna and dnaassociated proteins characterize systemic le. Systemic lupus erythematosus sle is a chronic, multisystem, autoimmune disease characterized by periods of increased disease activity caused by inflammation of blood vessels and connective tissue. Symptoms vary between people and may be mild to severe. Pdf pathophysiology of sle find, read and cite all the research you need on researchgate. Reduce inflammation, regain optimal mobility, reduce organ dysfunction, reduce number and frequency of flares systemic lupus erythematosus sle nursing care plan. Systemic lupus erythematosus overview the lupus initiative.
The exact pathoaetiology of systemic lupus erythematosus sle remains elusive. The pathophysiology of systemic lupus erythematosus includes the nervous system, digestion, heart, lungs, blood, muscles, bones, kidneys and skin. Treatment currently includes antimalarials, glucocorticoids, immunosuppressants, and biologics. Using the american college of rheumatology acr and systemic lupus international collaborating clinics slicc criteria to determine the diagnosis of systemic lupus erythematosus sle in patients with subacute cutaneous lupus erythematosus scle. Most people suffering from systemic lupus erythematosus will develop pain in their muscles, joints and peripheral joints such as joints in their hands and knees can often become inflamed. Genetics and pathogenesis of systemic lupus erythematosus and. The systemic lupus erythematosus is considered among the more leading nonspecific organ autoimmune diseases understood, it is now well established that this disease results from the interaction of multiple genetic and environmental factors, leading to inappropriate activation of the immune system. An extremely complicated and multifactorial interaction among various genetic and environmental factors is probably involved. The most common issue for patients suffering from systemic lupus erythematosus is to do with their joints somers et al 2007. Systemic lupus erythematosus sle is a chronic autoimmune disease affecting multiple organs. An extremely complicated and multifactorial interaction among. Systemic lupus erythematosus larissa lisnevskaia, grainne murphy, david isenberg systemic lupus erythematosus is a remarkable and challenging disorder.
Systemic lupus erythematosus sle is the prototypical systemic autoimmune disease and is characterized by a clinical course of flares and remissions. Approximately 4070% of patients with sle will develop lupus nephritis. The condition is much more than a positive antinuclear antibody ana. Systemic lupus erythematosus sle is a systemic autoimmune disease that predominantly affects the females female to male ratio is 9. Lupus is an autoimmune disease, which means that the immune system erroneously acts against its own healthy tissues. Studies have focused on the role of adaptive immunity, however recent findings show multiple elements of the immune system in systemic lupus erythematosus. Review pathogenesis of systemic lupus erythematosus. Pdf the exact pathoaetiology of systemic lupus erythematosus sle remains elusive.